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Compounds (solids, liquids, gasses) with well-defined isotopic compositions that act as the ultimate sources of accuracy in mass spectrometric measurements of isotope ratios.
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21-Desacetyldeflazacort-d5 is a deuterium-labeled analytical reference standard of 21-desacetyldeflazacort for research use. It is designed to support accurate quantification of the active metabolite in biological samples and to improve precision in method validation and pharmacokinetic studies.
Deuterium-labeled isotopologue for mass-spectrometry assays.
High purity (>99.3%) for analytical reliability.
Molecular weight 404.51 g/mol, well characterized.
Suitable as an internal standard for LC-MS/MS and PK studies.
Available in small mg quantities for analytical workflows.
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Hydroxyzine-d8 is deuterium labeled Hydroxyzine. It functions as a histamine H1-receptor antagonist. This compound is suitable for use as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Used as a tracer
Internal standard for quantitative analysis
Histamine H1-receptor antagonist
Targets H1 receptor
Involved in GPCR/G protein, immunology/inflammation, and neuronal signaling pathways
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Nitroxoline-d4 is a deuterium-labeled form of Nitroxoline. Nitroxoline is an antibiotic effective against biofilm infections, primarily by chelating Fe2+ and Zn2+ ions from the biofilm matrix. This compound is intended for research use only and is not sold to patients. Deuterated compounds like Nitroxoline-d4 can serve as tracers for quantitation during drug development and may influence the pharmacokinetic and metabolic profiles of drugs.
Can be used as a tracer.
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Stable heavy isotopes of hydrogen, carbon, and other elements incorporated into drug molecules for quantitation during drug development.
Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
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Moxifloxacin-d4 (CAS No 2596386-23-9) is a deuterated derivative used in biomedical research primarily focused on bacteriology and pharmacokinetics Originating from synthetic modifications of the quinolone antibiotic moxifloxacin it functions by inhibiting bacterial DNA gyrase and topoisomerase IV essential enzymes for DNA replication This inhibition disrupts DNA processes leading to bacterial cell death Moxifloxacin-d4 exhibits potent antibacterial activity in vitro typically in the nanomolar to low micromolar range Its applications often include various cell models and animal studies to understand pharmacokinetics bioavailability and drug interaction Additionally it serves in drug screening processes to evaluate efficacy and metabolic pathways Experimental concentrations typically depend on the specific research design
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Dopamine-d4 hydrochloride (CAS No 203633-19-6) is a deuterium-labeled derivative of dopamine commonly used in biomedical research to study dopaminergic pathways and neurotransmitter dynamics Originating from synthetic processes it acts primarily on dopamine receptors influencing pathways associated with neurological and psychiatric functions Its activity is typically observed in the nanomolar to low micromolar range making it suitable for precise mechanistic studies This compound is often utilized in vitro in cell models to investigate receptor interactions and in animal studies to explore behavioral and physiological effects It is also employed in drug screening programs to evaluate potential therapeutic agents targeting neurological conditions Experimental concentrations typically depend on the specific research design ensuring flexibility in various study protocols
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Naphthalene-d8 (CAS No 1146-65-2) is a deuterated form of naphthalene often used in biomedical research for its stable isotopic labeling properties Originating from hydrocarbons it serves primarily in pharmacokinetic studies as a tracer due to its ability to integrate into various biological pathways without altering their function In vitro naphthalene-d8 is useful for analyzing metabolic processes often in nanomolar to low micromolar ranges It is commonly applied in cell models and animal studies to track and quantify metabolic changes improving the accuracy of drug screening and metabolic profiling Experimental concentrations typically depend on the specific research design
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