Isotope Standards
Medchemexpress LLC Alendronic acid-d6 | 1035437-39-8 | 98.0% | 5 MG
Alendronic acid-d6 is a deuterium labeled Alendronic acid. This bisphosphonate acts as a farnesyl diphosphate synthase (FDPS) inhibitor, effectively inhibiting osteoclast-mediated bone resorption. It has shown efficacy in treating postmenopausal osteoporosis, malignant hypercalcemia, and Paget's disease. Stable heavy isotopes, such as deuterium, are incorporated into drug molecules primarily as tracers for quantitative analysis during drug development, noting their potential to influence pharmacokinetic and metabolic profiles.
- Used as a tracer.
- Functions as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS).
- Inhibits osteoclast-mediated bone resorption.
- Effective in treating postmenopausal osteoporosis, malignant hypercalcemia, and Paget's disease.
- Deuteration can affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Nitroxoline-d4 (8-Hydroxy-5-nitroquinoline-d4) | 4008-48-4 | 1 MG
Nitroxoline-d4 is a deuterium-labeled form of Nitroxoline. Nitroxoline is an antibiotic effective against biofilm infections, primarily by chelating Fe2+ and Zn2+ ions from the biofilm matrix. This compound is intended for research use only and is not sold to patients. Deuterated compounds like Nitroxoline-d4 can serve as tracers for quantitation during drug development and may influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements incorporated into drug molecules for quantitation during drug development.
- Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
Cambridge Isotope Laboratories POTASSIUM PALMITATE (U-13C16, 98%+), 0.5 G
POTASSIUM PALMITATE (U-13C16, 98%+), 0.5 G
Medchemexpress LLC Simazine | 122-34-9 | 99.4% | 100 MG
Simazine is a triazine herbicide widely used in agriculture, potted plant, and tree production. It can induce apoptosis of immune cells in the spleen of mice and inhibit the proliferation of B cells and T cells in mice.
- Triazine herbicide
- Can inhibit maturation, disrupt spindle morphology, affect mitochondrial function, increase ROS levels, and induce DNA damage and early apoptosis of mouse oocytes
- Can lead to immunosuppression and immunotoxicity in mice
- Reduced proliferation of both spleen T and B cells in mice
- Decreased the number of spleen CD4+ T lymphocytes, while CD8+ T cells remained unchanged in mice
- Reduced immune function, higher intracellular [Ca2+], and oxidative stress in mice
- Induced spleen immune cell apoptosis by reducing Bcl-2, while increasing Fas and Caspase-3 levels in mice
- Appearance: Solid, white to off-white
Medchemexpress LLC Imidacloprid (Standard) | 138261-41-3 | 98.7% | 100 MG
Imidacloprid (Standard) is the analytical standard of Imidacloprid, intended for research and analytical applications. It is a widely used neonicotinoid pesticide effective against pests in various crops. This product is suitable for qualitative, quantitative, and methodological research experiments.
- Used for research and analytical applications.
- Effective against various pests.
- Suitable for HPLC, GC, and MS research.
- Provided as an analytical standard.
Cayman Chemical ImIdacloprId ImpurIty 1 250mg
A potential impurity in commercial preparations of imidacloprid
Chem Service Inc SIMAZINE 100MG
This item has a minimum order quantity of 2 per supplier requirements
Medchemexpress LLC Cycloguanil (hydrochloride) | 152-53-4 | >99.9% | 10 MG
Cycloguanil (hydrochloride) is a dihydrofolate reductase (DHFR) inhibitor, effective against human DHFR with an IC50 of 10.8 μM. It interferes with DNA replication by blocking the folate metabolic pathway, thereby affecting nucleotide synthesis. This compound is utilized in malaria research due to its ability to inhibit DHFR in *Plasmodium*, and also demonstrates anticancer activity by potently inhibiting DHFR in human cancer cells and blocking the transcriptional activity of STAT3.
- Blocks folate metabolic pathway
- Affects nucleotide synthesis and DNA replication
- Used in malaria research by inhibiting DHFR in *Plasmodium*
- Potently inhibits DHFR in human cancer cells
- Blocks transcriptional activity of STAT3, exhibiting anticancer activity
Cambridge Isotope Laboratories NITROBENZENE-D5 (D, 99%), 25 G, 4165-60-0
NITROBENZENE-D5 (D, 99%), 25 G, 4165-60-0
Sigma Aldrich Fine Chemicals Biosciences Enalaprilat dihydrate European Pharmacopoeia (EP) Reference Standard | 84680-54-6 | MFCD00941393 |
Enalaprilat dihydrate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 384.42 | 84680-54-6 | MFCD00941393 |
Sigma Aldrich Fine Chemicals Biosciences Isotopic standard for chlorine NIST(R) SRM(R) 975a | 7647-14-5 | MFCD00003477 |
Isotopic standard for chlorine NIST(R) SRM(R) 975a | Mol Wt: 58.44 | 7647-14-5 | MFCD00003477 |
Sigma Aldrich Fine Chemicals Biosciences Sodium bromide | 7647-15-6 | MFCD00003475 | 500 g
Sodium bromide | Purity: ≥99% | Mol Wt: 102.89 | 7647-15-6 | MFCD00003475 | 500 g